Botulinum toxin modulates basal ganglia but not deficient somatosensory activation in orofacial dystonia
Identifieur interne : 001781 ( Main/Exploration ); précédent : 001780; suivant : 001782Botulinum toxin modulates basal ganglia but not deficient somatosensory activation in orofacial dystonia
Auteurs : Christian Dresel [Allemagne] ; Ferdinand Bayer [Allemagne] ; Florian Castrop [Allemagne] ; Christoph Rimpau [Allemagne] ; Claus Zimmer [Allemagne] ; Bernhard Haslinger [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Anti-Dyskinesia Agents (pharmacology), Anti-Dyskinesia Agents (therapeutic use), Basal Ganglia (blood supply), Basal Ganglia (drug effects), Basal ganglion, Blepharospasm, Bontoxilysin, Botulinum Toxins (pharmacology), Botulinum Toxins (therapeutic use), Brain Mapping, Dystonia, Dystonic Disorders (drug therapy), Dystonic Disorders (pathology), Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Oxygen (blood), Physical Stimulation, Psychophysics, Reaction Time, Sensory Thresholds (drug effects), Sensory Thresholds (physiology), Somatosensory Cortex (blood supply), Somatosensory Cortex (drug effects), Somatosensory cortex, Touch (physiology), basal ganglia, blepharospasm, focal dystonia, functional MRI, somatosensory cortex.
- MESH :
- chemical , blood : Oxygen.
- chemical , pharmacology : Anti-Dyskinesia Agents, Botulinum Toxins.
- chemical , therapeutic use : Anti-Dyskinesia Agents, Botulinum Toxins.
- blood supply : Basal Ganglia, Somatosensory Cortex.
- drug effects : Basal Ganglia, Sensory Thresholds, Somatosensory Cortex.
- drug therapy : Dystonic Disorders.
- pathology : Dystonic Disorders.
- physiology : Sensory Thresholds, Touch.
- Aged, Brain Mapping, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Physical Stimulation, Psychophysics, Reaction Time.
Abstract
The etiology of idiopathic orofacial dystonia is incompletely understood. Neurophysiological studies indicated that a sensory dysfunction could play a key role in the pathophysiology of focal dystonia. To explore if central sensory processing is abnormal in patients with blepharospasm and Meige's syndrome and to study the effects of botulinum toxin (BTX) treatment, we systematically mapped the somatotopic representations of punctate tactile stimuli in these patients before and after therapy. Methods:: Standardized tactile stimuli were pseudorandomly applied to the forehead, upper lip, and hand by a MR‐compatible stimulation device during event‐related fMRI. Results:: Patients showed a deficient activation in primary and secondary somatosensory representations of affected and unaffected (right hand) body regions compared to healthy controls. Although clinically effective BTX treatment did not modulate this impaired cortical activation, it reduced the activation of the thalamus and contralateral putamen during forehead stimulation. Conclusions:: This study reveals a more generalized dysfunction of the somatosensory cortex including asymptomatic body representations in orofacial dystonia. Deficient cortical sensory activation may be due to a dedifferentiation of somatosensory representations and could represent a critical functional change within the basal ganglia‐thalamocortical loops facilitating dystonic movements. Modulation of basal ganglia activation might reflect an indirect remote effect of BTX treatment on these sensorimotor circuits. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23497
Affiliations:
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Muenchen</wicri:regionArea><wicri:noRegion>Technische Universitaet Muenchen</wicri:noRegion><wicri:noRegion>Technische Universitaet Muenchen</wicri:noRegion></affiliation></author><author><name sortKey="Haslinger, Bernhard" sort="Haslinger, Bernhard" uniqKey="Haslinger B" first="Bernhard" last="Haslinger">Bernhard Haslinger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Muenchen</wicri:regionArea><wicri:noRegion>Muenchen</wicri:noRegion><wicri:noRegion>Muenchen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1496">1496</biblScope><biblScope unit="page" to="1502">1502</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">91DBF2C6A18BF93D45B3BE466A7D0C92D1F21C28</idno><idno type="DOI">10.1002/mds.23497</idno><idno type="ArticleID">MDS23497</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anti-Dyskinesia Agents (pharmacology)</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Basal Ganglia (blood supply)</term><term>Basal Ganglia (drug effects)</term><term>Basal ganglion</term><term>Blepharospasm</term><term>Bontoxilysin</term><term>Botulinum Toxins (pharmacology)</term><term>Botulinum Toxins (therapeutic use)</term><term>Brain Mapping</term><term>Dystonia</term><term>Dystonic Disorders (drug therapy)</term><term>Dystonic Disorders (pathology)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Oxygen (blood)</term><term>Physical Stimulation</term><term>Psychophysics</term><term>Reaction Time</term><term>Sensory Thresholds (drug effects)</term><term>Sensory Thresholds (physiology)</term><term>Somatosensory Cortex (blood supply)</term><term>Somatosensory Cortex (drug effects)</term><term>Somatosensory cortex</term><term>Touch (physiology)</term><term>basal ganglia</term><term>blepharospasm</term><term>focal dystonia</term><term>functional MRI</term><term>somatosensory cortex</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Basal Ganglia</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Sensory Thresholds</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sensory Thresholds</term><term>Touch</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Physical Stimulation</term><term>Psychophysics</term><term>Reaction Time</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term><term>Bontoxilysin</term><term>Cortex somatosensoriel</term><term>Dystonie</term><term>Imagerie RMN</term><term>Noyau gris central</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The etiology of idiopathic orofacial dystonia is incompletely understood. Neurophysiological studies indicated that a sensory dysfunction could play a key role in the pathophysiology of focal dystonia. To explore if central sensory processing is abnormal in patients with blepharospasm and Meige's syndrome and to study the effects of botulinum toxin (BTX) treatment, we systematically mapped the somatotopic representations of punctate tactile stimuli in these patients before and after therapy. Methods:: Standardized tactile stimuli were pseudorandomly applied to the forehead, upper lip, and hand by a MR‐compatible stimulation device during event‐related fMRI. Results:: Patients showed a deficient activation in primary and secondary somatosensory representations of affected and unaffected (right hand) body regions compared to healthy controls. Although clinically effective BTX treatment did not modulate this impaired cortical activation, it reduced the activation of the thalamus and contralateral putamen during forehead stimulation. Conclusions:: This study reveals a more generalized dysfunction of the somatosensory cortex including asymptomatic body representations in orofacial dystonia. Deficient cortical sensory activation may be due to a dedifferentiation of somatosensory representations and could represent a critical functional change within the basal ganglia‐thalamocortical loops facilitating dystonic movements. Modulation of basal ganglia activation might reflect an indirect remote effect of BTX treatment on these sensorimotor circuits. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Dresel, Christian" sort="Dresel, Christian" uniqKey="Dresel C" first="Christian" last="Dresel">Christian Dresel</name></noRegion><name sortKey="Bayer, Ferdinand" sort="Bayer, Ferdinand" uniqKey="Bayer F" first="Ferdinand" last="Bayer">Ferdinand Bayer</name><name sortKey="Castrop, Florian" sort="Castrop, Florian" uniqKey="Castrop F" first="Florian" last="Castrop">Florian Castrop</name><name sortKey="Haslinger, Bernhard" sort="Haslinger, Bernhard" uniqKey="Haslinger B" first="Bernhard" last="Haslinger">Bernhard Haslinger</name><name sortKey="Rimpau, Christoph" sort="Rimpau, Christoph" uniqKey="Rimpau C" first="Christoph" last="Rimpau">Christoph Rimpau</name><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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